Akali vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Akali vs Vayne

Updated Jun 4, 2026

Overview

Akali must pressure early and deny Vayne a calm scaling lane by using her mobility and burst to force trades.
This is a snowball matchup where Akali's early agency and all-in windows are key to prevent Vayne from scaling safely.

Trading pattern

Start trades with (Q) poke and passive autos, then commit using (W) to obscure and (E) to follow up when Vayne is exposed.
Avoid using (W) if Vayne can simply wait it out or step out, as this leaves you vulnerable to counterattack.
Punish (E) cooldown by engaging aggressively before she can (E) you into terrain.

Danger windows

Vayne is most dangerous when (E) is available to (E) into walls; avoid fighting near terrain without (W) safety.
Be cautious after using (W) if Vayne can step out or wait it out, as you become vulnerable to her ranged damage.
Track (R) window for stealth repositioning to avoid getting caught in lethal trades or all-ins.

Early game

Use level 1-3 to safely poke with (Q) and create windows with (W) to engage before Vayne reaches key dueling power.
Avoid extended trades when (W) is down to prevent Vayne's ranged poke and disengage from punishing.
Maintain wave control to prevent Vayne from safely farming and scaling without pressure.

Power spikes

Level 3 unlocks Akali's full (Q)-(W)-(E) combo; use this to force trades when cooldowns and spacing favor you.
Level 6 (R) grants Akali strong all-in and escape; track its availability for picks or defensive plays.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun, especially in confined spaces.

Win conditions

Use (W) to create safe windows for extended trades and all-ins, denying Vayne safe farm and scaling.
Exploit cooldown windows on (E) and (R) to commit to burst trades or roams.
Snowball lane pressure into side-lane picks or flank pressure to leverage Akali's burst and mobility against Vayne's fragility.