Anivia vs Vayne ADC Matchup Guide | LaneStomp

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Anivia

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ADC

Vayne

Anivia vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on punishing Vayne's close-range last-hit attempts using (Q) and (E) combo.
Anivia wins extended trades with zoning and waveclear; Vayne wins short trades with mobility.
Hold wave near your side to deny Vayne safe dash angles and force her into your zone control.

Trading pattern

Step forward to auto and cast (Q)+(E) when Vayne commits to low-health minions and enemy support is out of zone range.
Use (W) to block Vayne's dash paths and force her into your (Q) stun for reliable trades.
Drop punish windows if enemy support controls brush or can immediately counter-engage after your step forward.

Danger windows

Avoid stepping up when (E) is off cooldown near walls to prevent her pinning you into terrain.
Respect enemy support presence and brush control that enable immediate follow-up after (Q) reposition.
Be cautious when (R) is active, as her stealth (Q) allows unpredictable all-in angles.

Early game

Use first three waves to thin caster minions and punish Vayne's last hits when her support can't trade back.
Avoid pushing early to prevent Vayne from using (Q) aggressively with support follow-up.
At level 2, prioritize landing (Q) to set up (E) damage during Vayne's vulnerable last-hit animations.

Power spikes

After level 6 and first mana/AP item, use (R) to zone and force Vayne to farm under pressure, limiting her dash angles.
Vayne's level 6 (R) grants stealth repositioning; respect this by avoiding extended trades without your (Q) and (W) ready.
Post first item, increase wave pressure to force Vayne into risky last-hit attempts you can punish with (Q)+(E).

Win conditions

Convert zoning and wave control into denied CS leads by punishing Vayne's last-hit attempts safely.
Crash waves to force Vayne under turret, reducing her dash space and all-in threat.
Use lane priority and item spikes to secure dragon vision and teamfight positioning for scaling advantage.