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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Annie vs Lissandra MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Annie

VS

Mid

Lissandra

Annie vs Lissandra

Confidence mediumUpdated Jun 10, 2026

Overview

Use medium lane pressure to deny Lissandra a controlled, poke-heavy lane.
Focus on finding picks with (R) followed by (Q) and (W) burst combos.
Avoid extended trades early to prevent getting rooted or stunned by her crowd control.

Trading pattern

Engage with (Q) + (W) combo when Lissandra is out of (W) range and passive is ready.
Punish Lissandra if she uses (E) aggressively without a safe recast.
Avoid trades when (R) is available to prevent lockdown counters.

Danger windows

(R) stun and (W) root create lethal all-in windows; avoid fighting without stun ready.
Be cautious when (E) is off cooldown, as she can engage or escape.
Watch for jungle backup enabling Lissandra's crowd control chain.

Early game

Farm safely until level 6, then look for (R) pick opportunities.
Avoid pushing with (W) to conserve mana and reduce vulnerability to all-ins.
Maintain spacing to dodge (W) root and (R) stun early trades.

Power spikes

Level 6 unlocks (R), enabling strong burst picks and roams.
First completed AP item significantly increases burst damage and trade threat.
Respect Lissandra's level 6 (R) for her lockdown and self-peel potential.

Win conditions

Secure kills by landing (R) then follow with (Q) and (W) burst before she reacts.
Deny Lissandra wave control to force her into reactive play.
Use (R) pick potential to roam and snowball other lanes if lane kills are limited.

Tip: For Annie vs Lissandra, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup