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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Annie vs Zilean MID Matchup Guide | LaneStomp

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Champion

Opponent

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Annie

VS

Mid

Zilean

Annie vs Zilean

Confidence mediumUpdated Jun 10, 2026

Overview

Use (R) to find picks and burst Zilean quickly before he can react with (R).
Avoid pushing the wave with (W) unnecessarily to conserve mana and prevent overextension.
Punish Zilean's reliance on bomb placement by dodging and engaging when bombs are on cooldown.

Trading pattern

Trade with (Q)+(W) combo when you have 4 passive stacks for guaranteed stun and burst.
Step forward to trade only when Zilean’s bombs are on cooldown or missed.
Avoid extended trades that force you to push the wave and drain mana.

Danger windows

Respect Zilean's double bomb stun combo when bombs are placed on the wave or slowed targets.
Avoid extended trades when Zilean’s (R) is available to prevent being negated by revive.
Be cautious when Zilean uses (E) to speed his ADC, as it enables enemy kiting and countertrades.

Early game

Focus on farming safely until level 6 when (R) becomes a strong pick tool.
Avoid standing in minion waves where Zilean can land double bombs for stun.
Track (Q) cooldown to punish missed bombs with burst trades.

Power spikes

Level 6 unlocks (R), enabling strong all-ins or roams; use it for confirmed picks.
First completed AP item boosts burst damage and wave pressure; increase aggression post-item.
Post-(R) cooldown is a window to punish Zilean’s reduced threat and force resets.

Win conditions

Use (R) to initiate picks and follow up with (Q)+(W) burst to snowball lane control.
Force Zilean to burn (R) defensively, then punish his cooldowns with aggressive trades.
Roam after pushing wave post-(R) to leverage your burst and create map pressure.

Tip: For Annie vs Zilean, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup