Caitlyn vs Vayne ADC Matchup Guide | LaneStomp

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Opponent

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Caitlyn

VS

ADC

Vayne

Caitlyn vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

Caitlyn wins short trades by punishing Vayne's close-range CS attempts with superior range.
Hold wave near enemy turret to force Vayne into vulnerable last-hit positions under trap zones.
Avoid extended trades where Vayne's true damage and mobility outscale Caitlyn's poke.

Trading pattern

Auto Vayne during her last-hit animations only if enemy support cannot punish your forward step.
Layer (W) traps on retreat paths and turret edges to zone Vayne’s dash angles.
Hold (E) for enemy engage attempts instead of using it aggressively for poke to maintain safety.

Danger windows

Avoid trading when (E) is down, as Vayne can engage with (E) wall stun.
Respect enemy support presence in brush or river that can follow up on Vayne’s engage.
Be cautious when Vayne activates (R) and uses (Q) stealth repositioning for all-in attempts.

Early game

Use level 1 range advantage to harass Vayne when she steps up for caster minions.
Push first three waves to set up trap lines around turret for plate pressure.
Keep (E) ready to disengage if enemy support threatens engage during early trades.

Power spikes

Level 1 range advantage lets Caitlyn punish Vayne's early CS attempts before her mobility spikes.
First completed marksman item strengthens poke and crash potential to secure plates and dragon control.
Two-item siege power spike increases turret pressure and zone control, limiting Vayne's safe farming.

Win conditions

Convert wave crashes into turret plates by trapping escape paths and forcing Vayne under tower.
Use lane priority and poke to deny Vayne safe farm and force early recalls.
Leverage early item spikes and support cooldowns to control dragon vision and teamfight positioning.