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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Cassiopeia vs Annie MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Cassiopeia

VS

Mid

Annie

Cassiopeia vs Annie

Confidence mediumUpdated Jun 10, 2026

Overview

Use mid-range sustained damage to punish Annie's short burst if poison is maintained.
Deny Annie picks by spacing well and using (W) to block her mobility and escape.
Focus on extended trades where repeated (E) outdamages Annie's burst combo.

Trading pattern

Initiate trades by landing (Q) or (W) to apply poison, then spam (E) for damage.
Use (W) to ground Annie's mobility and trap her in extended fights.
Avoid trading when (W) is down or (Q) misses to prevent Annie's burst punishes.

Danger windows

Annie's passive stun plus (Q)+(W) burst is lethal without poison or (W) ready.
Respect (R) as a pick tool that can start or follow up all-ins.
Trading without (W) up increases risk from Annie's mobility and burst.

Early game

Poke with early (Q) and (W) to force Annie's mana use and exploit her weak waveclear.
Avoid short trades without poison to prevent Annie's passive stun burst.
Hold mid-range spacing to prevent Annie stacking her passive for stun.

Power spikes

Level 6 (R) grants a strong all-in deterrent and pick potential.
First mana/AP item boosts sustained trade damage and mana pool.
Track Annie's level 6 (R) to avoid risky trades during its uptime.

Win conditions

Win extended fights by applying poison and using repeated (E) while controlling space with (W).
Deny Annie easy picks by maintaining mid-range control and punishing her mana weaknesses early.
Use (R) to lock down Annie during all-in attempts, turning her burst windows into kill opportunities.

Tip: For Cassiopeia vs Annie, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup