Cassiopeia vs Qiyana MID Matchup Guide | LaneStomp

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Cassiopeia

VS

Mid

Qiyana

Cassiopeia vs Qiyana

Confidence mediumUpdated Jun 10, 2026

Overview

Control mid-range space to force Qiyana into extended trades where poison and repeated (E) excel.
Maintain medium lane pressure to deny Qiyana easy access to terrain for her (R) impact and roams.
Focus on sustained DPS and anti-mobility zoning rather than burst or quick all-ins.

Trading pattern

Initiate trades by landing (Q) or (W) to apply poison, then extend with repeated (E) damage.
Punish (E) if used without lethal threat by trapping her with (W) and sustaining damage.
Avoid trading when (W) is down or (Q) misses, as Qiyana can exploit reduced control.

Danger windows

Qiyana is most dangerous when she has the correct element set and fights near terrain or brush for (R) stun.
Avoid all-ins when (R) is up and you lack (W) or (R) to counter her engage.
Be cautious if (E) is available with no defensive cooldowns, as she can dash and burst quickly.

Early game

Use (Q) to apply poison before trading; avoid trades without poison to reduce Qiyana's burst threat.
Hold (W) to ground (E) dash, punishing her if she commits without cooldowns.
Prioritize farming and poke to build mana and AP for stronger post-level 6 trades.

Power spikes

Level 6 (R) enables punishing Qiyana when she commits facing you near terrain; track its availability.
First mana/AP item boosts sustained trade potential; pressure waves more confidently after item.
Respect Qiyana's level 3 spike unlocking full (Q)-(W)-(E) combo and dash for burst trades.

Win conditions

Win extended trades by applying poison with (Q) and maximizing (E) damage while using (W) to trap her mobility.
Deny Qiyana access to terrain and brush to reduce her (R) impact and burst potential.
Use (R) to punish Qiyana when she faces you during all-ins, turning fights in your favor.