Dr. Mundo vs Ryze TOP Matchup Guide | LaneStomp

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Ryze

Dr. Mundo vs Ryze

Updated Jun 3, 2026

Overview

Dr. Mundo aims to survive early pressure by farming safely with (Q) and passive crowd control block while scaling into a durable frontliner.
Avoid giving Ryze passive farming windows by using (Q) to contest wave control and maintain lane presence without overcommitting.

Trading pattern

Trade only when (Q) lands repeatedly to slow Ryze and create chase or disengage space.
Use your passive to block (W) root and punish his cooldowns with extended trades.
Avoid trading if (Q) misses or passive is down, as Ryze can kite and counterpoke effectively.

Danger windows

Be cautious when Ryze has full mana and cooldowns, enabling repeated (E) and (Q) rotations plus (W) root setups.
Avoid extended trades before level 6 and health item spikes, as you are more vulnerable to Ryze's burst.
Respect (W) root cooldown; when it's up, he can lock you down for follow-up damage.

Early game

Use (Q) to farm safely and manage spacing, avoiding extended trades before level 6.
Respect (W) root threat by not stepping into range without passive protection.
Avoid missing (Q) as it reduces your ability to safely farm and control trades early.

Power spikes

At level 6, activate (R) before Ryze's burst to heal through damage and chase or disengage.
After your first health item, pressure side waves to force Ryze to spend time cutting through your durability.
Respect Ryze's first mana/AP item spike by playing more cautiously as his spell rotations become more threatening.

Win conditions

Survive early lane with safe (Q) farming and passive use, then outlast Ryze with superior health scaling and (R) healing.
Use your durability to absorb damage in side lanes and front-to-back fights, forcing Ryze to waste cooldowns.
Pressure side waves post-health item spike to deny Ryze easy scaling and force him into unfavorable fights.