Ezreal vs Vayne ADC Matchup Guide | LaneStomp

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Ezreal

VS

ADC

Vayne

Ezreal vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Ezreal landing (Q) poke through minions to punish Vayne's short-range CS attempts.
Ezreal wins short trades by poking safely, while Vayne excels in extended fights post-level 6.
Maintain wave states that prevent Vayne from safely using (Q) to reposition and punish your poke.

Trading pattern

Punish Vayne when she steps out from minion cover to last-hit, but only if enemy support can't immediately trade back.
Use (Q) poke on low-health caster minions to hit Vayne without entering her dash range.
Avoid extended auto trades; back off if (E) is down to prevent her all-in with (E) and (R) stealth.

Danger windows

(E) wall stun combined with support follow-up creates lethal all-in windows; respect this when (E) is available.
After Ezreal uses (E), he is vulnerable to Vayne's engage and must play cautiously.
Avoid stepping into brush or river zones controlled by enemy support to prevent hook or stun setups.

Early game

Use the first three waves to thin minions and create poke angles where (Q) can hit Vayne out of minion cover.
Avoid using (E) aggressively early without support cover to prevent (E) wall stun punish.
Track (Q) reposition cooldown to avoid stepping into her auto range during last-hit windows.

Power spikes

First completed item spike lets Ezreal contest wave and objectives with safer repeated (Q) poke.
Two-item spike increases poke threat, enabling control of fights before Vayne can engage.
Level 6 (R) allows wave clear and finishing low-health targets, pressuring Vayne's scaling window.

Win conditions

Convert poke damage into forced recalls or health leads to crash waves and take turret plates.
Use lane priority from repeated (Q) hits to secure dragon vision and contest objectives.
Scale safely into mid-game item spikes to outpoke and kite Vayne in teamfights, avoiding extended DPS trades.