Garen vs Vayne TOP Matchup Guide | LaneStomp

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Garen vs Vayne

Updated Jun 3, 2026

Overview

Garen should focus on controlling short trades and avoid extended fights where Vayne's mobility and true damage dominate.
Maintain lane pressure to prevent Vayne from freely scaling and kiting in the side lane.
This is a mid-scaling juggernaut vs late-scaling ranged marksman matchup where Garen must survive early and leverage execute windows.

Trading pattern

Initiate short trades with (Q) silence followed by (E) spin damage, then disengage before Vayne can kite or retaliate.
Punish (E) cooldown by engaging when it is unavailable to reduce her threat of wall stuns.
Avoid prolonged trades that allow Vayne to stack true damage from (W) and reposition with (Q).

Danger windows

Be cautious when Vayne has (E) ready near walls, as she can stun and punish Garen heavily.
Avoid trading when Garen's passive health regeneration is not recovered, as extended poke from Vayne can overwhelm him.
After using (Q), Garen has limited reach; avoid overcommitting before it returns to prevent being kited or stunned.

Early game

Use early waves to farm safely and look for short trades when (E) is down.
Avoid engaging when (Q) reposition or (E) wall stun is available to prevent being kited or stunned.
Prioritize passive health regeneration by spacing trades and backing off quickly after damage exchanges.

Power spikes

At level 6, use (R) execute to finish off low-health Vayne targets after chipping her down with short trades.
After first defensive or bruiser item, Garen can absorb more damage and repeat trades safely, forcing Vayne to respect his durability.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun, which increase her outplay potential and kill threat.

Win conditions

Use (Q) silence and (E) short trades to chip Vayne's health and create execute opportunities with (R) after level 6.
Maintain passive health regeneration by spacing trades and avoiding poke to sustain lane presence.
Deny Vayne safe scaling by controlling lane pressure and forcing her into risky positions where (E) is less effective.