Gwen vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Gwen vs Vayne

Updated Jun 3, 2026

Overview

Prioritize scaling through safe farming and stacking (Q) before committing to extended trades against Vayne's ranged harassment.
Use (W) to negate Vayne's poke and create windows for longer fights where Gwen's AP damage excels.
This is a scale-focused matchup where Gwen must manage lane pressure to avoid giving Vayne easy ranged poke or disengage.

Trading pattern

Engage trades only after stacking (Q) and when (W) is available to block Vayne's retaliation.
Use (E) to control spacing and prevent Vayne from kiting effectively or hitting (E) into walls.
Punish Vayne when she wastes (E) or commits to short trades without her stealth repositioning from (R).

Danger windows

Vayne is most dangerous when (R) is active, enabling stealth (Q) repositioning and aggressive (E) wall stuns.
Gwen is vulnerable when (W) is down before Vayne commits; avoid trades during this cooldown.
Beware of Vayne's high early poke and burst potential before Gwen reaches item spikes; avoid risky engagements then.

Early game

Focus on stacking (Q) on minions to build trade potential while avoiding early burst from Vayne's ranged autos and (Q).
Use (E) to maintain spacing and dodge (E) wall stun attempts.
Avoid extended trades before level 6 when (R) slow and chase threat is unavailable.

Power spikes

Level 6 (R) is a major spike; use it to slow and chase Vayne for kill pressure after setting up with stacked (Q).
Two-item AP spikes greatly enhance Gwen's dueling power; pressure side lanes and force extended fights inside (W).
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun as windows where she can outplay committed all-ins.

Win conditions

Reach key AP item spikes and stack (Q) consistently to dominate extended trades and side-lane duels.
Use (W) to negate Vayne's ranged poke and force fights inside the mist where Gwen's damage excels.
Pressure side lanes and join teamfights where (W) protects Gwen, enabling sustained DPS and chase with (R).