Kai'Sa vs Miss Fortune ADC Matchup Guide | LaneStomp

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Kai'Sa

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ADC

Miss Fortune

Kai'Sa vs Miss Fortune

Confidence highUpdated Jun 7, 2026

Overview

This lane turns on wave state: Kai'Sa needs thinned waves to maximize (Q) damage on isolated Miss Fortune.
Miss Fortune wins extended poke and wave pressure; Kai'Sa must avoid long trades without support setup.
Kai'Sa scales better with item spikes and (R) reposition, thriving in short all-ins after poke cooldowns.

Trading pattern

Punish Miss Fortune stepping up for caster or cannon minion last hits when enemy support can't counter.
Avoid using (E) aggressively before enemy poke or support engage cooldowns expire.
Use (W) to mark and start plasma stacks only after support CC isolates Miss Fortune or after she wastes (Q).

Danger windows

(Q) bounce on low-health minions punishes Kai'Sa standing too close or last-hitting poorly.
Avoid trading or stepping forward when Miss Fortune's support can immediately follow or zone from brush.
(E) slow enables safer poke and (R) setup; respect this window to prevent burst all-ins.

Early game

Use first three waves to farm safely behind minions, avoiding (Q) bounce angles that punish last hits.
At level 2, respect (Q) bounce and (E) slow; only trade if support can threaten CC.
Thin waves early to isolate Miss Fortune from minions, enabling stronger (Q) trades and burst windows.

Power spikes

First completed item unlocks evolved abilities, enabling Kai'Sa to threaten safe all-ins with (Q) and (R).
Level 6 (R) allows repositioning onto marked targets, turning short trades into kills with support CC.
Evolved (Q) damage is strongest when Miss Fortune is isolated, so prioritize wave control to create these windows.

Win conditions

Convert item and evolve spikes into all-ins when support CC starts plasma stacks on Miss Fortune.
Use wave thins and last-hit punishments to force Miss Fortune recalls and secure turret plates.
Leverage (R) reposition in teamfights to dive isolated targets, maximizing Kai'Sa's mixed damage and burst potential.