Lissandra vs Annie MID Matchup Guide | LaneStomp

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Lissandra

VS

Mid

Annie

Lissandra vs Annie

Updated May 31, 2026

Overview

Lissandra controls the lane by punishing Annie's short range and burst reliance with her W root and R lockdown.
Focus on denying Annie safe all-in windows and avoid extended poke trades where Annie can stack her passive safely.

Trading pattern

Trade when Annie is forced to use Annie W to push and is low on mana, as she becomes vulnerable to your W root and follow-up.
Use W to punish Annie's close-range all-ins and follow with R to lock her down before she can proc her stun.
Avoid trades when R is down, as Annie's burst combo and passive stun can punish your cooldowns.

Danger windows

Annie is dangerous when her passive stun is stacked and Annie R is available for pick attempts.
Avoid extended trades or engaging without R ready, as Annie's burst combo can quickly punish you.
Be cautious when your E is used forward without follow-up, as Annie can capitalize on your positioning.

Early game

Use Q to farm and poke Annie to force her out of range and prevent easy passive stacks.
Hold W to root Annie when she tries to commit for her Q+W combo, punishing her burst attempts.
Avoid engaging with E unless R and jungle follow-up are ready to secure lockdown and counter Annie's burst.

Power spikes

Respect Annie's level 6 spike with R, which enables her strong pick potential and burst.
Lissandra's level 6 R is a major spike to lock down Annie or negate her all-ins.
First completed AP or utility item enhances Lissandra's control and burst, increasing threat against Annie.

Win conditions

Use Q to control wave and poke Annie out of range, forcing her to use mana inefficiently.
Punish Annie's attempts to all-in by rooting her with W and locking down with R for your team to follow up.
Coordinate with jungle to capitalize on your lockdown chain and shut down Annie's burst potential early.