Lissandra vs Sett MID Matchup Guide | LaneStomp

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Lissandra

VS

Mid

Sett

Lissandra vs Sett

Updated Jun 3, 2026

Overview

Lissandra should control the wave with (Q) and hold (W) to punish Sett's melee engages, denying him easy brawls.
This is a control vs teamfight matchup where Lissandra must avoid giving Sett passive melee trades and leverage her lockdown for picks and skirmishes.

Trading pattern

Trade when Sett commits into (W) range, using (W) root and (R) lockdown to neutralize his grit trades.
Punish Sett after he wastes (E) or misses his (W) center by stepping forward with (Q) and (W).
Avoid forcing fights without (R) as Sett's melee damage and grit shield overpower sustained trades.

Danger windows

Sett is most dangerous when he has grit stacks and can land centered (W); maintain spacing to avoid his damage peak.
Be cautious when (E) is up as it can pull and stun, enabling his all-in trades.
Lissandra is vulnerable when (R) is down; avoid extended trades and prepare to disengage or farm safely.

Early game

Use (Q) to safely farm and poke Sett before he can engage with (E) or (W).
Avoid extended trades without (W) and (R) ready to prevent Sett from building grit and winning brawls.
Track (E) cooldown to punish missed pulls with aggressive (W) roots and (E) flanks.

Power spikes

Level 6 (R) is Lissandra's biggest threat increase; use it for picks or defensive resets when Sett commits.
First completed AP or utility item boosts Lissandra's wave pressure and trade reliability; increase aggression accordingly.
Respect Sett's level 6 (R) slam and first bruiser item spikes by maintaining spacing and avoiding forced melee trades.

Win conditions

Use layered crowd control with (W) and (R) to lock Sett or his follow-up for ganks and teamfights.
Deny Sett's melee trades by controlling wave position and punishing his cooldowns, preventing him from scaling.
Create flank engages with (E) and coordinate with jungle or roams to secure kills and snowball lane control.