Lissandra vs Zoe MID Matchup Guide | LaneStomp

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Lissandra

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Mid

Zoe

Lissandra vs Zoe

Updated May 31, 2026

Overview

Lissandra is a control mage who must manage Zoe's long-range poke and pick potential by controlling wave and spacing.
Prioritize denying Zoe safe angles for Zoe E and avoid giving her passive lane pressure to limit her poke and burst.

Trading pattern

Trade only when Zoe's Zoe E is on cooldown or missed, as it is her key setup and damage amp.
Use W to root Zoe if she tries to all-in after missing Zoe E, then follow with R for lockdown.
Avoid using E aggressively without backup since Zoe can punish predictable engages or punish if R is down.

Danger windows

When Zoe's Zoe E is up and aimed, respect her poke and avoid walking into her bubble range.
If Lissandra's R is down, she is more vulnerable to Zoe's burst and pick attempts.
Avoid engaging without jungle follow-up as Zoe can punish Lissandra's forward E or cooldowns.

Early game

Use Q to farm safely and hold W to punish Zoe if she tries to commit after landing Zoe E.
Respect Zoe's high early poke and avoid extended trades if Zoe's E is off cooldown.
Coordinate with jungle for follow-up when you use E to flank or engage after Zoe wastes Zoe E.

Power spikes

Lissandra's level 6 R is a major power spike for lockdown and self-peel.
Zoe's level 6 R extends her poke range and burst threat; respect this to avoid lethal trades.
First completed AP or utility item significantly boosts Lissandra's control and damage potential.

Win conditions

Use W and R to lock down Zoe when she commits or after she misses Zoe E to set up kills.
Control the wave with Q and deny Zoe angles for Zoe E by positioning and wave management.
Coordinate with jungle or team to punish Zoe's cooldowns and force skirmishes where your CC chain excels.