Miss Fortune vs Vayne ADC Matchup Guide | LaneStomp

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Miss Fortune

VS

ADC

Vayne

Miss Fortune vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

Miss Fortune wins short poke trades using (Q) bounce angles against Vayne's melee CS attempts.
Vayne thrives in extended trades and side-lane duels; Miss Fortune must force quick poke windows.
Control wave states to deny Vayne safe last hits behind low-health minions and force recalls.

Trading pattern

Punish Vayne stepping up for last hits only if enemy support can't immediately counter-engage.
Use (E) slow to secure safer (Q) bounces and prevent (Q) repositioning.
Avoid trading when no low-health minions allow (Q) bounce or if enemy support controls brush zone.

Danger windows

Respect (E) wall stun when near terrain; avoid stepping into narrow spaces without support peel.
Beware (R) stealth repositioning combined with (Q) for burst trades when she has space to kite.
Avoid trading if enemy support controls brush or can follow up instantly on your step forward.

Early game

Use first three waves to thin caster minions and create (Q) bounce angles punishing Vayne's last hits.
At level 2, avoid overextending since (Q) dash enables quick retaliation if support threatens.
Hold wave near your side to limit Vayne's dash space and reduce her all-in threat.

Power spikes

Level 6 (R) lets Miss Fortune turn support CC into lethal teamfight damage; hold for choke points.
First completed damage item strengthens (Q) poke, enabling easier recalls and plate pressure.
Use (E) slow combined with (R) to lock down Vayne who lacks dash during ultimate channel.

Win conditions

Convert (Q) poke into health leads forcing Vayne recalls, enabling plate and dragon control.
Pair (R) with allied CC in narrow terrain to maximize damage and secure kills.
Use wave pressure and poke to deny Vayne safe farm, delaying her scaling and side-lane dueling power.