Mordekaiser vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Mordekaiser vs Vayne

Updated Jun 3, 2026

Overview

Mordekaiser aims to control lane tempo by forcing extended trades where his passive and (W) shield sustain outvalue Vayne's poke.
Prioritize denying Vayne safe scaling by using (E) to pull and isolate her, preventing her from kiting effectively.
This is a control versus scaling matchup; Mordekaiser must pressure to avoid giving Vayne room to use her mobility and range advantage.

Trading pattern

Initiate trades by threatening or landing (E) to pull Vayne into your passive range, then hit isolated (Q) for max damage.
Only extend trades when (W) shield is charged to convert damage into healing, mitigating Vayne's true damage and poke.
Avoid trading when (E) is on cooldown or passive is inactive, as Vayne can kite and punish with (Q) and (W) true damage stacks.

Danger windows

Vayne is most dangerous when (E) is up to pin you into terrain and (R) is active granting stealth repositioning.
Missing (E) leaves you vulnerable to Vayne's kiting and true damage; avoid walking forward without engage threat.
Be cautious of Vayne's all-ins near walls where (E) can stun; avoid fighting in tight spaces without (E) or (R) advantage.

Early game

Use early waves to position for (E) pulls, threatening Vayne's limited mobility before level 6.
Avoid overcommitting if (E) misses, as Vayne can punish with her high mobility and (Q) reposition.
Build and maintain a slow wave to keep Vayne in range for extended trades and to limit her ability to safely poke from distance.

Power spikes

At level 6, use (R) to isolate Vayne and force duels she struggles to escape, especially when you have health or item advantage.
First AP bruiser item spike increases your sustained damage and durability; force longer trades only when (E) or wave state keeps Vayne nearby.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun; avoid committing when these are available and she has space to kite.

Win conditions

Win by controlling the wave and using (E) to force Vayne into extended trades where your passive and (W) shield outscale her poke.
Use (R) after a successful (E) pull to isolate Vayne from team help and force favorable duels.
Deny Vayne safe scaling by maintaining lane pressure and punishing her mobility cooldowns to prevent her from snowballing side-lane duels.