Naafiri should focus on using (Q) poke to chip Sett before committing to all-ins, managing medium lane pressure to avoid giving Sett easy melee trades.
This is a snowball matchup where Naafiri must leverage mobility and burst to punish Sett's low mobility and interruptible engage tools.
Trading pattern
Start trades by landing (Q) to apply bleed, then wait for Sett to use (E) or (W) before committing with (W) and (E).
Avoid engaging when (Q) poke is missed or (W) shield is active.
Use (R) to enhance chase and punish Sett when isolated or low health, especially after Sett wastes his crowd control or (W).
Danger windows
Be cautious when Sett has built grit and his (W) shield is up, as his trades become much stronger.
Avoid engaging when (E) stun is available, especially near minions to prevent getting pulled and stunned.
Respect Sett's level 6 (R) slam, which can reposition Naafiri into dangerous fights or crowd control combos.
Early game
Use early (Q) poke to create health advantage and avoid melee range where Sett builds grit for his (W).
Avoid committing (W) engage without prior poke or when Sett's crowd control (E) is available.
Track (E) cooldown to prevent getting stunned or pulled into unfavorable trades.
Power spikes
At level 6, use (R) to increase all-in threat and chase potential; track (R) cooldown to time aggressive plays.
After first lethality item, pressure Sett more confidently as (Q) poke and burst become more threatening.
Respect Sett's level 6 (R) displacement and his first bruiser item timing, which increase his brawl potential and survivability.
Win conditions
Win lane by consistently landing (Q) poke to lower Sett's health and force him to miss his melee trades.
Use (W) and (R) windows to all-in when Sett's crowd control or shield is down, focusing on isolating him.
Leverage mobility and pack synergy to roam or reset fights, snowballing through picks and denying Sett's scaling.
Tip: For Naafiri vs Sett, read overview, trading pattern, and danger windows first for a fast Mid lane check.