Nilah vs Vayne ADC Matchup Guide | LaneStomp

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Nilah

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ADC

Vayne

Nilah vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Nilah surviving early poke and punishing Vayne's short-range CS attempts.
Nilah wins committed all-ins with (W) blocking autos and (R) pulling targets in close.
Vayne controls wave priority with range and kiting, so Nilah needs support setup to engage safely.

Trading pattern

Step forward to auto punish Vayne when she commits to last hits inside your (Q) range and support threat is low.
Use (W) to block Vayne's retaliatory autos during all-ins initiated by your support engage.
Avoid using (E) forward without support follow-up to prevent being kited by (Q) stealth reposition.

Danger windows

Respect (E) wall stun combo when near terrain, especially if enemy support controls brush.
Avoid trading when (W) is down, as Vayne can punish your autos with true damage and repositioning.
Be cautious stepping forward if enemy support can immediately follow or zone you during last-hit punish attempts.

Early game

Use first three waves to farm near your turret and avoid stepping into (Q) auto punish.
Punish Vayne's last-hit attempts on low-health caster minions only if enemy support can't zone.
Avoid pushing early to deny Vayne space for (E) wall stuns and (Q) repositioning.

Power spikes

Level 6 (R) enables Nilah to turn support engages into kills by pulling Vayne into your team.
First completed marksman item makes your all-ins more threatening and forces Vayne to respect your engage.
Vayne's level 6 stealth (R) and (Q) reposition require you to commit with support and (W) timing to avoid being kited.

Win conditions

Convert health leads from all-ins into crashing waves to deny Vayne CS and force recalls.
Use (R) with support engage to secure kills or force Vayne under turret before dragon setups.
Scale through protected farming and item spikes to out-damage Vayne in teamfights with your short-range burst and crowd control.