Quinn vs Vayne TOP Matchup Guide | LaneStomp

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Quinn vs Vayne

Updated Jun 3, 2026

Overview

Quinn should use her ranged pressure and (E) to deny Vayne safe farm and prevent her from scaling comfortably.
Prioritize lane pressure and tempo to snowball early and avoid giving Vayne a passive, scaling lane.
This is a snowball vs scale matchup where Quinn must leverage early agency and roams to maintain control.

Trading pattern

Trade short bursts using (Q) to blind Vayne and prevent her auto retaliation.
Avoid extended melee fights where Vayne's true damage and mobility excel.
Punish Vayne when her (E) is down by stepping forward for aggressive trades or wave pressure.

Danger windows

Be cautious when (E) is available near walls, as she can stun and punish aggressive engages.
Avoid extended trades when (E) is down but Vayne's mobility (Q) and stealth (R) are active.
Hard push and take plates when Vayne roams, pinging danger to avoid losing tempo or ganks.

Early game

Use early ranged harass and (Q) blind to punish Vayne's attempts to last hit under pressure.
Hold (E) defensively to disengage Vayne's all-in attempts, especially near walls.
Crash waves proactively to create roam windows with (R) instead of staying in lane passively.

Power spikes

At level 6, use (R) to convert lane pressure into map tempo and side-lane picks before Vayne can scale.
After first damage item, increase ranged poke and burst potential to pressure isolated Vayne and force her to waste (E).
Respect Vayne's level 6 (R) stealth and repositioning; avoid fighting in tight spaces where she can (E) into walls.

Win conditions

Use Quinn's ranged poke and (E) spacing to deny Vayne farm and force her into defensive play.
Crash waves and roam aggressively with (R) to create side-lane pressure and pick opportunities.
Maintain lane tempo to prevent Vayne from scaling into her late-game DPS power spikes.