Ryze vs Cassiopeia MID Matchup Guide | LaneStomp

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Champion

Opponent

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Ryze

VS

Mid

Cassiopeia

Ryze vs Cassiopeia

Updated May 31, 2026

Overview

Ryze must manage his short range and mana to safely farm and scale against Cassiopeia's sustained poke and poison trades.
Avoid giving Cassiopeia extended mid-range control by using waveclear to deny her steady E damage and punish missed Cassiopeia Q.

Trading pattern

Use E to mark Cassiopeia and follow up with Q for poke, holding W to punish her commits or root her if she approaches.
Punish Cassiopeia when she misses Cassiopeia Q, as her immediate threat drops and she can't extend trades with Cassiopeia E.
Avoid trading when low on mana or when Cassiopeia's Cassiopeia W is up, as it grounds your mobility and blocks escapes.

Danger windows

Avoid extended trades when Cassiopeia's Cassiopeia W is available to ground your movement and block escapes.
Be cautious when Cassiopeia's Cassiopeia R is up and you are forced to face her, as it can stun or slow you.
Punish Cassiopeia's missed Cassiopeia Q to trade aggressively before she regains poison and sustained damage potential.

Early game

Focus on farming safely without stepping into Cassiopeia's Cassiopeia Q and W range early levels.
Use E and Q for short trades only when Cassiopeia's Cassiopeia W is down to reduce her zoning threat.
Avoid extended trades before level 6 when Cassiopeia's Cassiopeia R stun threat is lower.

Power spikes

Respect Cassiopeia's level 6 Cassiopeia R, which punishes Ryze for facing her during all-ins.
Ryze's first mana/AP item spike is crucial to sustain spell rotations and compete with Cassiopeia's scaling.
Ryze's level 6 R enables map plays and side pressure to relieve lane pressure and create advantages.

Win conditions

Scale through safe farming and use your waveclear to control the lane and deny Cassiopeia's poison application.
Use W root to lock Cassiopeia when she overcommits and follow up with E and Q for burst trades.
Leverage level 6 R to create side lane pressure and force Cassiopeia to respond, opening opportunities for your team.