Ryze vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Ryze vs Vayne

Updated Jun 4, 2026

Overview

Ryze is a scaling mage who must manage wave control and mana to safely farm against Vayne's ranged pressure.
Avoid giving Vayne free space to kite and poke by controlling the wave and punishing her when she steps forward.
This is a scale-versus-scale matchup where Ryze aims to outlast Vayne through sustained spell rotations and map plays.

Trading pattern

Trade by applying (E) to spread marks and follow with (Q) while holding (W) to root Vayne if she commits.
Avoid trading when low on mana or when (W) is on cooldown, as you lose your main control and damage tools.
Punish Vayne's use of (Q) forward or missed (E) by stepping up with spell rotations before she can reposition.

Danger windows

Be cautious when (E) is off cooldown and she has space to kite, as she can stun and punish you hard.
Avoid stepping forward to apply (E) or (W) if (R) is active, as her stealth (Q) increases her outplay potential.
Watch for gank windows if you push without vision, since Vayne's mobility and your short range make you vulnerable.

Early game

Prioritize safe farming and avoid extended trades before your first mana/AP item to reduce early poke damage.
Use (E) and (Q) for short trades only when you have mana and space, holding (W) to punish Vayne's all-in attempts.
Keep the wave controlled to prevent Vayne from safely poking or setting up (E) stuns near walls early on.

Power spikes

After your first mana/AP item, pressure the wave and trades more confidently while tracking Vayne's cooldowns.
At level 6, use (R) for map plays and coordinated all-ins, but avoid forcing fights without vision or jungle support.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun; avoid extended trades when these are available.

Win conditions

Scale safely through controlled farming and use waveclear to deny Vayne free poke or roam opportunities.
Use (W) root to catch Vayne when she overcommits or mispositions, then follow up with (Q) and (E) damage.
Convert wave control into side-lane pressure and coordinated map plays with (R) to outnumber and outmaneuver Vayne's dueling strength.