Sett should leverage his high early agency and lane pressure to force close-range trades and deny Sylas a calm scaling lane.
This matchup is a control vs snowball lane where Sett aims to dominate melee brawls and prevent Sylas from using his mobility and sustain effectively.
Trading pattern
Start trades by forcing close-range autos and use (E) to pull Sylas near minions for a stun, then spend grit on centered (W) for max damage and shield.
Punish Sylas's cooldowns by engaging after he uses (E) or (W) to reduce his sustain and escape options.
Avoid using (W) predictably to prevent Sylas from sidestepping and negating your true damage burst.
Danger windows
Be cautious when (E) is available as it provides knockup/stun and high mobility for engages or escapes.
Avoid extended trades when (W) heal is up, as he can sustain through your damage.
Watch for Sylas's level 6 (R) window to prevent being caught off guard by his ultimate's power and follow-up potential.
Early game
Use levels 1-3 to aggressively force melee trades with autos and (E) to build grit and punish Sylas before he unlocks his full combo.
Avoid extended trades if Sylas has (E) available to engage or disengage, and punish him hard when he misses (E).
Maintain wave control near mid to limit Sylas's ability to roam or safely use (R).
Power spikes
At level 6, use (R) to reposition Sylas into unfavorable fights or to isolate him for all-ins.
After completing your first bruiser item, increase wave pressure to force Sylas into risky trades or losing farm.
Respect Sylas's level 3 spike when he gains his full (Q)-(W)-(E) combo and his level 6 (R) for potential all-ins or roams.
Win conditions
Win the lane by forcing melee brawls where you can stack grit and land centered (W) for strong trades.
Use level 6 (R) to create advantageous fights or force Sylas into bad positioning.
Apply continuous wave pressure post-first item to deny Sylas farm and force him into unfavorable trades or missing experience.
Tip: For Sett vs Sylas, read overview, trading pattern, and danger windows first for a fast Mid lane check.