Sett vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Sett vs Vayne

Updated Jun 3, 2026

Overview

Sett should use his early lane pressure and brawling strength to deny Vayne a calm scaling lane and force her into uncomfortable trades.
Control the wave to keep Vayne within (E) range for stun setups and grit trades, preventing her from freely kiting and scaling.
This is a snowball vs scale matchup where Sett must leverage early aggression and level 6 all-ins to disrupt Vayne's scaling and side-lane threat.

Trading pattern

Start trades by forcing close-range autos and use (E) to pull Vayne near minions for stun opportunities.
Spend grit on centered (W) hits to maximize damage and shield before Vayne can sidestep or disengage.
Punish Vayne after she uses (E) to knock back or when she mispositions near walls by following up with (R) displacement.

Danger windows

Be cautious when (E) is available near walls, as it can stun and punish your engage attempts.
Avoid trading when your (E) is down, as your catch threat and stun potential significantly drop.
Watch for Vayne's level 6 (R) stealth tumbles that allow her to outplay committed all-ins; engage only with proper setup.

Early game

Use early melee trades with autos and (E) pulls to build grit and pressure Vayne before she can safely kite.
Keep the wave close to threaten (E) stuns and force Vayne to choose between losing farm or taking bad trades.
Avoid extended chases or pushing without vision to prevent ganks and keep lane control tight against Vayne's mobility.

Power spikes

At level 6, use (R) to reposition Vayne into unfavorable fights or terrain, forcing all-ins when she commits.
After first bruiser item, increase wave pressure to force Vayne into short trades and harder-to-avoid (W) hits.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun by engaging only when you have proper wave and cooldown advantage.

Win conditions

Win lane by forcing melee trades with autos and (E) stuns, then capitalizing on grit-backed (W) damage to dominate early fights.
Use level 6 (R) to create favorable brawls or isolate Vayne in side lanes, denying her safe scaling and farm.
Control wave and vision to keep Vayne in melee range and prevent her from safely kiting or scaling into late game.