Syndra vs Annie MID Matchup Guide | LaneStomp

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Syndra

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Mid

Annie

Syndra vs Annie

Updated May 31, 2026

Overview

Syndra is a burst control mage who wants to poke with Q and W, then punish Annie's engages with E stun into R burst.
Manage lane pressure by denying Annie's pick attempts and avoid giving her easy passive stacks for stun.

Trading pattern

Poke with Q and W to whittle Annie down, holding E to punish her all-in attempts or follow-up on her R engages.
Respect Annie's passive stun and R Tibbers burst by spacing carefully and only engaging when E is available.
Capitalize on Annie's mana constraints by pressuring her to push with W, then punish her vulnerability with E into R.

Danger windows

Syndra is most vulnerable when E is on cooldown, as she lacks mobility and escape tools.
Annie's passive stun on 4th stack and R Tibbers engage create lethal all-in windows to respect.
Missing spells or spheres reduces Syndra's threat and opens her to Annie's burst combos.

Early game

Use Q and W to poke Annie early and force her to use mana, exploiting her weak waveclear and mana pool.
Avoid committing without E ready, as missing E leaves you vulnerable to Annie's burst and stun combo.
Focus on controlling space to prevent Annie from stacking her passive safely for trades.

Power spikes

Syndra's major spikes are level 6 R for burst all-ins and first completed mage item for stronger poke.
Annie's major spikes are level 6 R for pick potential and her first AP item for increased burst.
Syndra's Q max at 11 and 16 lowers cooldown and boosts poke, increasing E stun threat frequency.

Win conditions

Use Q and W to control lane and poke Annie out of range, forcing her to burn mana and struggle to farm.
Look for E stuns on well-placed spheres to punish Annie's attempts to engage or follow up on her R.
Secure level 6 and item spikes to burst Annie down before she can retaliate or roam effectively.