Twitch vs Vayne ADC Matchup Guide | LaneStomp

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Twitch

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ADC

Vayne

Twitch vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

Twitch wins by punishing Vayne's close-range CS attempts using stealth and poison stacks.
Avoid early fair trades; lane favors Vayne's high mobility and short-trade strength.
Hold wave near your side to create stealth (Q) windows and deny Vayne easy last hits.

Trading pattern

Step forward to auto or (W) slow when Vayne commits to last-hitting under no enemy support threat.
Avoid punishing if enemy support controls brush or threat zone to prevent counter-engage.
Stack poison with (W) and autos before using (E) to cash out damage on Vayne staying too long after being tagged.

Danger windows

Avoid stepping forward when (E) is up, threatening wall stuns and engage.
Respect enemy support presence in brush or river, which can enable Vayne's short-range burst trades.
Be cautious after (Q) is revealed or on cooldown, as Twitch loses stealth safety and becomes vulnerable.

Early game

Use first three waves to farm safely and avoid direct trades before level 3.
Punish Vayne's last-hit attempts on low-health caster minions only if enemy support is out of position.
Avoid pushing wave early to prevent Vayne from using (Q) aggressively with support follow-up.

Power spikes

Level 6 (R) spike lets Twitch open fights from stealth and punish grouped targets near minions.
First completed marksman item increases Twitch's damage and all-in threat after stealth engages.
Two-item stealth spike enables Twitch to flank and carry teamfights, forcing vision control from enemies.

Win conditions

Survive lane to reach level 6 and item spikes where stealth picks become viable.
Use stealth and (R) to punish Vayne grouped near minions or support, converting into plates or dragon control.
Force Vayne under tower early to limit her mobility and scale safely into late-game DPS role.