Vayne vs Caitlyn ADC Matchup Guide | LaneStomp

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Vayne

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ADC

Caitlyn

Vayne vs Caitlyn

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Vayne punishing Caitlyn's short-range last-hit attempts with (Q) autos.
Vayne wins extended trades and scales harder, but must avoid Caitlyn's early poke and trap zones.
Hold wave near your side to deny Caitlyn safe poke angles and reduce her trap effectiveness.

Trading pattern

Hit Caitlyn during low-health minion last-hit animations with (Q) autos only if enemy support can't immediately punish.
Avoid using (Q) forward when (E) is ready to dash away or when she has trap zones set.
Hold (E) to (E) Caitlyn into lane walls after she uses (E) for disengage or when she oversteps for CS.

Danger windows

Respect (W) trap zones layered with support CC or turret edges that root and zone you.
Avoid stepping up when (E) is off cooldown, as she can disengage and punish your all-in attempts.
Be cautious trading when enemy support controls brush or river, enabling immediate follow-up on your punish attempts.

Early game

Use the first three waves to hold a slow push near your tower and punish Caitlyn stepping up for caster minions.
At level 2, avoid walking into (W) trap zones and only punish last hits if enemy support cannot counter.
Keep vision on river and brush to prevent Caitlyn from safely placing traps that limit your mobility.

Power spikes

Level 6 (R) lets you stealth reposition with (Q), enabling safer extended trades and wall stuns.
Your two-item spike turns you into a major anti-tank threat, allowing side-lane pressure and duels Caitlyn can't match.
Caitlyn's first marksman item strengthens her poke and plate pressure; contest wave crash before this timing.

Win conditions

Convert last-hit punish windows into health leads to force Caitlyn off the wave and deny plates.
Use level 6 stealth (R) and (Q) repositioning to win extended trades and secure side-lane pressure post-lane.
Scale into your two-item spike to outduel Caitlyn in side lanes and provide high true damage DPS in teamfights.