Vayne vs Camille TOP Matchup Guide | LaneStomp

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Vayne

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Camille

Vayne vs Camille

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to deny Camille's short trades and avoid her engage angles.
Pressure Camille to avoid letting her use terrain for (E) engages and respect her lockdown (R) at level 6.
Focus on scaling into a side-lane duelist who punishes Camille's reliance on locked-down picks.

Trading pattern

Trade by auto-attacking from max range, using (Q) to maintain spacing and reposition safely.
Hold (E) to (E) Camille into terrain when she commits to (E) or (R) engages.
Avoid using (Q) forward when Camille's engage is ready to prevent being caught in lockdown.

Danger windows

Camille is most dangerous when (E) is available from terrain and second (Q) true damage is primed; maintain spacing and vision.
Level 6 (R) lockdown greatly increases Camille's all-in threat; use your (R) stealth to counterplay or disengage.
Be vulnerable if you push without vision or waste (Q) forward, as Camille can punish with (E) engage and (R) lockdown.

Early game

Keep the wave on your side to reduce Camille's safe (E) angles and limit her short trade opportunities.
Use (E) to punish Camille's engage attempts when she tries to approach near walls.
Avoid pushing without vision to prevent ganks and punish Camille's hard engage potential.

Power spikes

At level 6, use (R) to gain stealth repositioning and outplay Camille's all-in lockdown.
After first marksman item, pressure Camille with true damage and kite space to exploit her lower sustained damage.
Respect Camille's first sheen-style item spike when her second (Q) true damage trade becomes reliable; avoid extended fights then.

Win conditions

Deny Camille's terrain access and (E) engage angles by controlling wave position and spacing.
Use (E) to punish overextensions and (R) to outplay lockdown attempts during side-lane duels.
Scale into a late-game anti-tank DPS marksman who pressures side lanes and kites Camille's engage in teamfights.