Vayne vs Dr. Mundo TOP Matchup Guide | LaneStomp

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Dr. Mundo

Vayne vs Dr. Mundo

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to deny Dr. Mundo safe farm and punish his low early lane pressure.
Prioritize scaling through lane pressure and avoid giving Mundo passive farm or extended trades where he outlasts you.

Trading pattern

Trade from max range using autos and (Q) to maintain spacing and avoid Mundo's slow and cleaver.
Punish Mundo when (Q) misses or his passive is down by stepping forward for short trades.
Avoid fighting near walls unless you can guarantee (E) will stun Mundo and secure a kill or disengage safely.

Danger windows

Be cautious when Mundo's (Q) lands repeatedly, as it creates chase potential and slows your escape.
Avoid extended trades when Mundo's (R) is active, as his healing and durability spike significantly.
Watch for ganks especially if you push without vision, since Mundo's low early lane pressure can be deceptive.

Early game

Keep the wave on your side to avoid overextending and reduce gank risk.
Use (Q) to poke and reposition, avoiding pushing without vision to prevent hard engages.
Hold (E) to punish Mundo's engage attempts or to (E) him into walls for stuns.

Power spikes

At level 6, use (R) stealth and empowered (Q) to outplay Mundo's all-ins and reposition safely.
After first two core items, pressure side lanes aggressively as your true damage makes Mundo vulnerable.
Respect Mundo's level 6 (R) healing and movement speed by disengaging or kiting during his healing window.

Win conditions

Deny Mundo safe farm by using ranged poke and (Q) to maintain distance and control wave state.
Scale into a side-lane duelist with two items and use (E) to lock Mundo against walls for kills.
Use (R) stealth repositioning to outplay Mundo's engages and pressure side lanes while avoiding his healing windows.