Vayne vs Ezreal ADC Matchup Guide | LaneStomp

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Vayne

VS

ADC

Ezreal

Vayne vs Ezreal

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Vayne punishing Ezreal stepping up for last hits behind minions.
Vayne wins extended trades and scales better; Ezreal controls poke but struggles versus true damage.
Hold wave near your side to force Ezreal into short-range CS contests and punish with (Q) autos.

Trading pattern

Step forward to auto Ezreal during his last-hit animations if his support cannot zone or engage.
Hold (E) to (E) Ezreal into walls after he uses (E) aggressively or misses (Q).
Avoid using (Q) forward when (E) is up to prevent being counter-engaged or poked down.

Danger windows

(E) reposition combined with (Q) poke creates a window where stepping up is risky.
When enemy support controls brush or threat zone, avoid last-hit punish attempts to prevent counter-engage.
Avoid trading when (E) is available, as he can dodge your (E) and punish your positioning.

Early game

Use the first three waves to hold a freeze near your tower, denying Ezreal safe poke angles.
Punish Ezreal's last hits on low-health caster minions only if enemy support cannot immediately trade back.
Avoid pushing early without vision to prevent (Q) poke and (E) reposition punishing you.

Power spikes

Level 6 (R) grants stealth repositioning and dueling power; use it to outplay Ezreal's poke and all-ins.
First completed item spike lets you punish Ezreal stepping up for CS more safely and contest plates.
Two-item true damage spike enables side-lane duels where Ezreal struggles to match sustained DPS.

Win conditions

Convert last-hit punishments into health leads to force Ezreal recalls and crash waves for plates.
Use side-lane pressure after two-item spikes to force Ezreal into unfavorable fights or split.
Leverage (R) stealth tumbles in teamfights to access backline and maximize true damage output.