Vayne vs Kalista ADC Matchup Guide | LaneStomp

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Vayne

VS

ADC

Kalista

Vayne vs Kalista

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on punishing Kalista's short-range last-hit attempts with (Q) autos and (E) terrain stuns.
Vayne wins extended trades by kiting and stacking true damage, while Kalista thrives in long-range skirmishes with support engage.
Hold wave near your side to deny Kalista safe hop angles and reduce her (E) stacking opportunities.

Trading pattern

Step forward to auto Kalista when she commits to last-hitting inside your (Q) reposition range and support threat is minimal.
Hold (E) to (E) Kalista into bot lane walls for a stun, especially when she overextends for CS.
Avoid using (Q) forward if Kalista's support can immediately follow up with engage or crowd control.

Danger windows

Respect (R) engage window when her support can pull her in for all-ins.
Avoid trading when Kalista has full (E) stacks ready to execute and her support is positioned aggressively.
Do not punish last hits if enemy support controls brush or can instantly counter-engage after your step forward.

Early game

Use the first three waves to hold a freeze near your tower, forcing Kalista into risky short-range CS.
Punish Kalista's last hits on low-health minions only if enemy support is out of engage range.
Avoid pushing early without vision to prevent Kalista's support from setting up all-ins with (R).

Power spikes

Level 6 (R) lets you stealth reposition and outplay Kalista's short-range all-ins; use it when you have space to kite.
First marksman item spike increases your damage and lane pressure, enabling safer last-hit punishments.
Two-item spike turns you into a strong side-lane duelist against Kalista, forcing her to avoid isolated fights.

Win conditions

Convert last-hit punishments into crash waves to deny Kalista plates and force early recalls.
Use lane priority and vision to secure dragon setups where (E) execute pressure is less effective.
Scale into side-lane duels post two-item spike, leveraging (W) true damage and (E) wall stuns to dominate fights.