Vayne vs Samira ADC Matchup Guide | LaneStomp

Back to matchup selector

Champion

Opponent

RoleGenerate matchup

Vayne

VS

ADC

Samira

Vayne vs Samira

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on punishing Samira's short-range CS attempts with (Q) autos and (E) wall stuns.
Vayne wins extended trades and scaling, while Samira thrives on grouped all-ins with support engage.
Hold wave near your side to deny Samira dash resets and force her into risky short trades.

Trading pattern

Step forward to auto Samira during her last-hit animations only if enemy support can't immediately trade back.
Use (Q) to reposition and punish Samira when she dashes in without (W) active or after she wastes (E).
Hold (E) to (E) Samira into lane walls for stuns, especially when she overextends for CS or after her dash is spent.

Danger windows

Samira is dangerous when her support lands CC, enabling her (E) dash resets and (R) AoE burst.
Avoid stepping up when (W) is ready to block your key poke or when enemy support controls brush.
Beware of Samira dashing in immediately after your (Q) is used forward or (E) is on cooldown.

Early game

Use the first three waves to hold a safe freeze near your tower to limit Samira's dash access.
Punish Samira's last-hit attempts on caster minions when her (W) is down and support cannot contest.
Avoid pushing without vision to prevent Samira's support from setting up engages that enable her (E) resets.

Power spikes

Level 6 (R) grants stealth on (Q), enabling safer repositioning and outplays against Samira's all-ins.
First two-item spike boosts true damage, allowing Vayne to outduel Samira in side-lane skirmishes.
Samira's level 6 (R) and first item spike increase her all-in threat; respect her engage only after support CC.

Win conditions

Convert last-hit punishments into health leads to crash waves and take turret plates early.
Use level 6 stealth and two-item true damage to pressure side lanes and force Samira under turret.
Leverage lane priority and vision to set up safe recalls and dragon control, scaling into late-game DPS dominance.