Vayne vs Varus ADC Matchup Guide | LaneStomp

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Vayne

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ADC

Varus

Vayne vs Varus

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Vayne punishing Varus's immobility during last-hit attempts with (Q) autos.
Vayne wins extended trades through true damage and (E) terrain stuns, while Varus controls lane with poke and root threat.
Vayne wants a thinned or slow-pushed wave near her side to safely punish CS and avoid Varus's charged (Q) poke.

Trading pattern

Punish Varus's last-hit animations with (Q) autos only if enemy support can't immediately trade back.
Avoid stepping forward when (Q) is charged or (R) root is available to prevent burst trades.
Use (E) to (E) Varus into walls after he commits to poke or when support cooldowns allow follow-up.

Danger windows

(R) root combined with support follow-up creates lethal all-in windows; avoid stepping forward then.
Charged (Q) poke from Varus is dangerous when Varus has space and vision to safely charge it.
Losing brush control or stepping into enemy support's threat zone opens Varus's engage and poke opportunities.

Early game

Use the first three waves to thin the wave and punish Varus when he commits to low-health minions.
Avoid pushing without vision to prevent Varus charging (Q) safely and setting up poke angles.
Hold (E) for wall stuns when Varus or support overextends during CS or poke attempts.

Power spikes

Level 6 (R) empowers Vayne's dueling and stealth repositioning, letting her outplay Varus's root.
First marksman item spike strengthens Vayne's burst, enabling safer trades and better CS punishment.
Two-item spike turns Vayne into a strong side-lane duelist, pressuring Varus who lacks mobility.

Win conditions

Convert last-hit punishments into health leads to force Varus recalls and secure plate gold.
Use wave states near your tower to deny Varus safe poke angles and crash waves for dragon setup.
Scale into side-lane duels post two-item spike, exploiting Varus's lack of mobility and hard engage.