Vayne vs Vladimir TOP Matchup Guide | LaneStomp

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Vladimir

Vayne vs Vladimir

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to pressure Vladimir early and deny him a calm scaling lane.
Prioritize lane pressure and poke to prevent Vladimir from safely farming and scaling into his late-game burst.

Trading pattern

Trade using autos at max range and (Q) to reposition, avoiding trading when Vladimir's empowered (Q) is up.
Punish Vladimir after he uses (W), as it has a long cooldown and leaves him vulnerable.
Hold (E) to (E) Vladimir into walls for stuns, especially when he commits to short trades.

Danger windows

Be cautious when (W) is available, as it grants untargetability and can negate your engage.
Respect Vladimir's empowered (Q) trades; avoid trading when it is ready.
Avoid pushing without vision to prevent ganks that Vladimir can capitalize on due to your low waveclear.

Early game

Keep the wave on your side to avoid being vulnerable to Vladimir's short trades and healing.
Avoid pushing without vision to reduce risk from ganks and Vladimir's potential (W) counter-engage.
Hold (E) to punish Vladimir's approach or force him away from walls where you can stun him.

Power spikes

Level 6 (R) empowers your dueling and stealth repositioning; use it to outplay Vladimir's all-ins.
Two-item side-lane spike increases your true damage threat; pressure side lanes with vision and kite space.
Respect Vladimir's level 6 (R) burst window and his first completed AP item timing; avoid extended trades then.

Win conditions

Use your superior range and mobility to deny Vladimir safe farming and scaling.
Exploit windows after Vladimir uses (W) to engage or punish him before his AP spikes.
Scale into your two-item power spike to dominate side-lane duels and apply pressure with true damage and (E) wall stuns.