Vayne vs Zeri ADC Matchup Guide | LaneStomp

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Vayne

VS

ADC

Zeri

Vayne vs Zeri

Confidence mediumUpdated Jun 7, 2026

Overview

Vayne wins by punishing Zeri's short-range CS attempts using (Q) reposition and (E) wall stuns.
The lane hinges on denying Zeri free last hits near walls where she gains (E) mobility.
Vayne scales better into extended duels and side-lane DPS, while Zeri prefers long fights around terrain.

Trading pattern

Step forward to auto-attack Zeri during her last-hit animation when enemy support is out of zone range.
Use (Q) to reposition and punish Zeri's predictable CS paths, especially near walls to threaten (E) stuns.
Avoid using (Q) forward if enemy support controls brush or threat zone, as it exposes you to engage.

Danger windows

Respect (E) dash cooldown; she is vulnerable after using it without a wall escape.
Avoid trading when enemy support can immediately follow or control brush for engage.
Beware extended fights with (R) active, as she gains strong mobility and DPS uptime.

Early game

Use the first three waves to hold the wave near your side, limiting (E) dash options.
Punish Zeri stepping forward on low-health caster minions only if enemy support can't immediately respond.
Avoid pushing without vision to prevent losing (E) as an escape and getting locked down by enemy engage.

Power spikes

Level 6 (R) grants stealth tumbles and dueling power; use it to outplay Zeri's extended fights.
First marksman item spike enhances your true damage and all-in threat; pressure side lanes safely.
Two-item spike turns you into a major anti-tank threat; force isolated duels away from walls.

Win conditions

Convert last-hit punishments into health leads to force Zeri off waves and crash for plates.
Use lane priority and item spikes to pressure dragon setups and force Zeri under tower.
Scale into side-lane duels and teamfights where your true damage and (R) stealth reposition excel.