Zed vs Vex MID Matchup Guide | LaneStomp

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Zed

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Mid

Vex

Zed vs Vex

Updated Jun 1, 2026

Overview

Zed is a high-agency assassin who wants to pressure Vex early and deny her passive fear from controlling trades.
Use your high lane pressure to prevent Vex from comfortably using her passive and R to dominate trades.

Trading pattern

Engage with W + E for guaranteed damage, follow up with Q to finish, and use R for all-in when Vex's fear is down.
Punish Vex if she fails to land her passive fear or if Vex's R is on cooldown by committing to your combo.
Avoid trading when Vex's passive fear is up as it can easily proc electrocute and punish your aggression.

Danger windows

Be cautious when Vex's passive fear is available, as it can disrupt your trades and enable her to proc electrocute.
Avoid all-in attempts if you miss W or if Vex's R is up, as she can reset and punish you hard.
Before level 3, you are especially vulnerable to Vex's pressure and should play more cautiously.

Early game

Avoid extended fights before level 3 as Zed is vulnerable and can be bullied by Vex's fear and poke.
Use W + E + Q combo after level 3 to poke and threaten all-ins, forcing Vex to respect your burst.
Watch for Vex's passive fear timing to avoid getting caught in her short trades early.

Power spikes

Zed's major spikes: level 3 (W-E-Q combo), level 6 (R), and first lethality item.
Respect Vex's level 6 spike with Vex R as it enables her to reset and punish your all-ins.
Vex's first completed AP burst item increases her threat, so be cautious around this power spike.

Win conditions

Use your high burst and mobility to deny Vex's passive fear by forcing short trades and punishing missed abilities.
All-in with R when Vex's R is down or after baiting her fear to secure kills or summoner spells.
Maintain lane pressure to prevent Vex from safely scaling and force her into unfavorable fights.